First of all, it is obvious that we will be playing season 2 as Clem, who is still a child. From the trailer, I'm guessing she is probably 10, and definitely no older than 11. I have a feeling that Clementine's age will come into effect when other characters interact with you.
For example, people might assume that you aren't able to pull your weight/ be useful in a group because you are still just a kid. Even though she will have survived (partially on her own) probably over a year since the outbreak, most people might not see how useful she could be right away.
On the other hand, your age could be a benefit in some situations. Remember in episode 4 when Clem "puppy dog eyed" Molly into saving Lee, Kenny, and herself from walkers? Some people might just trust whatever she says/ be more inclined to help her because she is just a kid. After all, that's part of the reason why Lee decided to save her. On a darker note, you could use the sympathy some characters have for children and stab them in the back.
Lets get even darker. Some characters will probably see you as an easy target. I'm hoping that combat in this game is harder than in season one. While Clem is certainly a capable survivor at this point, she is going to have a hard time fighting grown men without weapons. On the plus side, at least you are a smaller target.
Clem, and by extension, the player is going to feel a lot more caution in regards to your safety. This is both due to the player's attachment to Clementine, and because Clem has probably figured out that just because she is little doesn't mean people will hesitate to hurt her.
How do you guys think Clem's age will impact the story?
This quote from Chuck sums up a lot of my thoughts about Clementine."
"She'll die a little girl if you treat her like one. You gotta consider her a living person. That's it. You're either living or you're not. You ain't little, you ain't a girl, you ain't a boy, you ain't strong or smart. You're alive."