This discussion may contain spoilers!
As terrible as it may seem, I think all signs point to Bigby being framed for the murder of Faith and Snow.
He was the person last seen with Faith AND Snow, and his bad reputation with the community may result in him becoming the easy target for the blame. And the Ginger Man (as he has become known) may be either a suspect OR a witness to support the fact that Bigby was last seen with the victims.
Aside from that, it looks like you're going to meddle in the marriage of Beauty and Beast and interrogate the pimp. It also looks like (depending on your choice) that the Woodsman is going to be going rogue in order to clear his name, or the Tweedles will be out for your blood.
And finally, we have the big questions: Where is Faith's body (and Snow's)? I suspect that it will show up in Bigby's apartment, thus implicating him. The flip-side to that is, if you gave Faith your matchbook rather than just light her cigarette, finding that matchbook might lead to her body.