This discussion may contain spoilers!
Out of all the alternate scenarios that could have developed from season one, I've always thought this was the most intriguing. Lily actually INVITES Lee to accompany her in the RV (if you chose to side with Lily in the meat locker), which begs the question of what might have been if Telltale wasn't obligated to stay within the confines of a set narrative. Otherwise, we could have seen the rest of season one branch out into a radically different path...beginning with the RV breaking down thirty miles down the road from an overheated radiator.
Let's speculate. Could a pseudo-romance have blossomed between Lee and Lily? Would Lily's hard-nosed survivalist attitude have prevented Lee's bite? Would the Stranger have pursued Lee, Lily, and Clem across the country to a completely different location?