This discussion may contain spoilers!
**Ok I'm mainly only talking about The Walking Dead and The Wolf Among Us.
I think if The Wolf Among Us was not a prequel to the comics it would give the writers at Telltale more creative freedom and they wouldn't have to worry about messing up the canon of the comics.
In The Wolf Among Us we will never see a romance between Bigby and Snow because that would go against the comics, we are never going to capture Ichabod Crane because when the comics started he was still in hiding away from Fabletown. We will never get to take down or kill Bluebeard because again he has to be alive and well for the comics to work and many other stuff we will not be able to do because it may go against the comics canon and worst of all we won't get many (Or maybe any more) seasons out of The Wolf Among Us because the comics has to start for the time-line to work.
Same thing goes for The Walking Dead:
We where never able to persuade Glenn to stay with us because of the comics. We where not able to kill Lilly for what she did because she needed to be alive for the comics. We will never be able to go to wood-bury and meet The Governor because of the comics.
Really its annoying that TV gets its own Walking Dead universe and lets the writers at HBO have all the creative freedom and look how successful that show is. Imagine what they could do with a RPG of Fables and The Walking dead.
I really think that The Wolf Among us and TellTale's The Walking Dead should be in its own universe and have its own continuity giving us the player the freedom to Role play and maybe wind up changing events that happened in the comics like saving people who where meant to die or killing a character who actually lived in the comics.
PLEASE NOTE: I don't hate the comics i think their great i just think that the video game versions should have its own continuity like how The Walking Dead comics and The Walking Dead TV show both have their own continuity.