This discussion may contain spoilers!
Through my own personal investigations on how the game is progression is going, I have come up with Two ideal conflicts that I got from the book of fables.
1.)** Bloody Mary**-Without a doubt, Bloody Mary is a huge threat in the game, and we will definitely be seeing her again, the question is how. Reading the book of fables reveals that Mary can travel through any mirror and appear. And what mirror is a important part of the game- thats right, the magic mirror in the woodlands. Even though the magic mirror has magical properties, the book of fables also mentions the she is immune to a spells and magic. AND!!! Remember in Episode 1 when Faith mentions that everyone knows were Bigby lives, Mary has an easy way into the Woodlands and Bigbys apartment through the magic mirror in Cranes office. (Maybe Buffkin is in harms way once the mirror is complete)
2.) Bigbys father- I know its a long shot but hear me out. Looking through the Achievement/Trophy list I found in episode 5 there was one called "The North Wind Blows" (or something like that). After reading this it reminded me of a entry in the book of fables called "Bigby's Vengeance" it tells the story tells of Bigby and his Father, The Northern Wind, Back in the homelands. It says Bigby tried to kill his father, but failed every time and eventually gave up, now that Bigby is older and stronger, could this be foreshadowing toward a future conflict. Of course, Since the Achievement/ Trophies were not that accurate in Episode 3, this might not be accurate as thought, but I think it is a great thing to think about