This discussion may contain spoilers!
In episode 4 it seems that Jane will be teaching Clem some things. Then, in the 'next time' preview, Jane says,
"They're all gonna die Clementine. Don't let them drag you down with them."
I bet that near the end of Episode 4, you'll be making a choice about whether you stick with Jane (Who may possibly run into someone like Luke), or stay with Kenny and the rest. This'll probably happen near Rebecca's baby scene. I could imagine it going something like this...
Jane and Clementine talking earlier
Jane: Clem, she's gonna get someone killed.
Clem: Who, Rebecca? There's nothing really wrong with her, she's nice.
Jane: The baby, Clem. That thing survives the birth and walkers'll be all over.
Clem: So? We can't help it. We'll just have to deal with it.
Jane: We should go. Together, me and you. We'd do good. Sticking with those guys'll just get you killed. So, what's it gonna be, you wanna be with me?
Then there'd be a choice that goes something like...
Agree with Jane
Clem: You're right, I guess. The baby's gonna be hard to raise. Maybe we should split up.
Jane: I know I'm right, I've been through this kind of stuff before. If people cry in you're group, you're as good as dead.
Disagree with Jane
Clem: We're not leaving anyone! The only reason I'm still alive is because I'm in a group, and it's staying that way.
Jane: Wha-, seriously? After all the stuff I taught you, this is what you say?
Clem: No one EVER get's left behind, you hear me?
Clem: I don't know, Jane. The baby would be loud, but in a group we'd handle it easily, right?
Jane: Definitely not, Clementine. A baby is always hard to deal with, especially in times like this.
Clem: I just...I just... Don't know.
Jane: Come with me, Clementine. You don't need them.
Jane: What? Is that a yes?
Jane: Sighs You're tough, Clem. You can do better than them.
Then, during the baby scene, near the end of the episode, you may have to make the REAL choice about who you go with. Jane (Who would probably end up running into Luke or something, as he seems to have disappeared), or Kenny, Rebecca and presumably Mike.
So, what do you guys think? I'd love feedback as well as your own ideas.