The game freezes up for about a second at a time, repeatedly, particularly when the camera angle changes. Sometimes lines or sounds will loop and then cut off or dialog will stall for a moment. I had the same issues with Walking Dead seasons 1 and 2. This makes for a very tedious experience, so hopefully it can be fixed.
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EDIT: I found the problem, as far as TWAU goes. A few days ago I was fooling around with Realtek HD Audio Manager and I enabled Headphone Virtualization. I tried going back to default settings on it and The Wolf Among Us' stuttering problem has been almost entirely eliminated. It's now more than playable.
This hasn't fixed the issue in The Walking Dead Season 2, though.