Murray: Denny Delk (just use a CGI skull or puppetry, no physical actor necessary)
Cutthroat Bill: Bob Hoskins
I would definitely cast Martin Short as Guybrush Threepwood mighty pirate!
He looks just like the comic book version of him in Monkey Island 3 (same nose and everything!) and he's about the right age for this last Monkey island game ;-)
imdb page: Martin Short imdb page
I firmly believe that Chris Pratt would be the best Guybrush
No way man! He looks more like smilin' Stan the salesman! http://monkeyisland.wikia.com/wiki/Stan_S._Stanman
sjacks16 posted: »I firmly believe that Chris Pratt would be the best Guybrush