This discussion may contain spoilers!
I noticed that, at least on my playthrough, Bigby seemed to be particularly offended any time someone dropped the B-bomb. Grendel and the Woodsman both let the aforementioned profanity fly from their salty mouths; and, respectively, they received a knuckle-sandwich (with extra knuckle) and a trip out of a two-story window, courtesy of Sheriff Bigby.
But it only just clicked for me that, as a kinda dog himself, it must really strike a nerve in Bigby whenever someone says 'b!tch' in a derogatory way. God help the poor sap who calls Bigby an 'SOB.'
So did anyone else manage to connect those particular dots?
Episode 3 Update: Walking in to the Puddin-n-Pie, we find Georgie who greets Bigby and Snow by calling the latter a Capital B-I-to-the-T-C-H. One of the options available is to then sock him in jaw. I'm chalking this up to another point in favor of my 'Big Bad B-Word Theory.'